The Golden Globes kicked off Hollywood awards season Sunday night — but the real winner of the night was Ozempic.

Viewers were quick to point out how many stars looked noticeably thinner than usual, leading to rife speculation about whether they’ve jumped on the Ozempic bandwagon.

Ana Reisdorf, a registered dietitian, told DailyMail.com: ‘I would not be surprised if most of the celebs at the Golden Globes were using GLP-1 to look their best for the show. GLP-1 is extremely effective for weight loss, even if you are already not overweight.’

Weight loss and plastic surgery specialists speculated that several A-list stars, including Nicole Kidman, Selena Gomez, Demi Moore, and Cynthia Erivo, had been taking Ozempic or other blockbuster weight-loss meds like Wegovy and Mounjaro.

They noted tauter faces, thinner arms, and more pronounced collarbones, which are highly suggestive features of weight loss.

Marlee Bruno, a board certified physician assistant based in Florida and founder of a med spa that prescribes semaglutide, told DailyMail.com that for celebrities at such high-profile events, with millions of people watching, plus countless cameras capturing photos that will last forever, the pressure to look flawless is immense.

Actress Kathy Bates stunned attendees at last night’s event with her slimmed-down figure and taut face. 

She has been open about her weight loss journey, which was helped by weekly Ozempic shots, and is one of the few celebrities who has admitted to using the medicine.

Nicole Kidman is pictured at the 2025 Golden Globe Awards

Ms Kidman’s backless dress revealed some loose skin, which could be due to aging, but is more likely a result of rapid weight loss from GLP-1 medication

Ms Moore’s collarbones are very prominent, with no visible fat, and her neck tendons are noticeable, indications that she may have used a GLP-1 medication

Most stars rumored to be taking semaglutide, which mimics a hormone in the body that signals the brain to stop eating, have flat-out denied allegations or simply ignored them.

Selena Gomez, a champion of self-love and body positivity, flaunted her naturally petite frame in an off-the-shoulder Prada gown.

She was noticeably slimmer at Sunday’s award ceremony, but experts doubt the star, who has been open about her ongoing battle with lupus, is taking a medicine like Ozempic. 

Dr Dennis Schimpf, a board-certified plastic surgeon, told DailyMail.com that Ms Gomez is ‘definitely thin,’ but she isn’t ‘wasting or gaunt, which is normally kind of the giveaway.’

He said: ‘Hers would be the hardest to know for sure. I would be surprised if she had done it just because of her other medical problems and her starting weight not being really heavy. 

‘I’ve read a few things about her and that she kind of adopted a more healthy lifestyle and exercises. ‘A lot of times, it’s not necessarily just one thing like the GLP treatment, but also kind of a combination of lifestyle as well as dietary habits.’

Nicole Kidman, who has not addressed Ozempic rumors, also stunned fans in a custom Balenciaga gown that showed off her sculpted arms and slim figure. 

Ms Bruno told DailyMail.com that, while Ms Kidman looked ‘stunning,’ her dress revealed a sign of rapid weight loss. 

She said: ‘Her backless dress, which looked stunning, did reveal some loose skin. This loose skin could be due to aging, but it’s more likely a direct result of rapid weight loss from GLP-1 medication.’

Ms Kidman has always been thin, but looser skin around her upper arms signaled to Dr Schimpf that she has lost significant fat in that area and possibly muscle. 

He said: ‘You’re losing subcutaneous fat. So the skin at that point, especially like at her age, the skin’s not really going to tighten much.

‘The skin is muscle, but because the medicine is putting their bodies in a deficit, a calorie deficit. 

‘The body basically breaks down fat for fuel or energy, until there’s not much fat left, and then it actually will break down muscle, because that’s the next kind of source of fuel or energy.’ 

While Selena Gomez appears thin, she doesn’t show signs of being severely underweight or gaunt, which are often key indicators

Over the past seven years, Kathy Bates dropped a total of 80lbs after focusing on a healthier lifestyle, and lost an additional 20lbs after using Ozempic; (R) Seen in 2015

In one of the night’s biggest surprises, Demi Moore won her first acting award for her performance in The Substance. 

To prepare for the film, she followed a strict diet and exercise regimen, including biking and dance cardio.

Ms Moore also fell victim to the shingles virus while filming, which she said caused her to drop 20 pounds.

Dr Sue Decotiis, a New York City-based weight loss doctor, told DailyMail.com: ‘Demi’s collar bones are really prominent. It looks like there’s no fat there at all. You can see her tendons in her neck. 

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‘Her face looks good but that can definitely be due to her injections.’ 

Dr Schimpf noted that a pronounced clavicle is a solid ‘giveaway’ that a star is using Ozempic or something similar. 

He added: ‘The people who’ve lost dramatic weight, and especially with those weight loss drugs, it’s almost like their head looks too big for their body.’ 

Cynthia Erivo and her Wicked co-stars Ariana Grande, Jeff Goldblum, Michelle Yeoh, and director Jon M Chu accepted the best box office achievement award.

Ms Erivo looked dramatically different in her chest and shoulders compared to the past. Experts suggested that she had lost a significant amount of subcutaneous fat, accentuating her upper chest bones

Ms Erivo, who has not addressed rumors of GLP-1 use, skyrocketed to stardom when it was announced that she would lead the Wicked cast as Elphaba in 2021. 

Dr Schimpf said: ‘She looked dramatically different in her chest and shoulders and than she had in the past.’ 

Ms Erivo, he said, had lost a significant amount of subcutaneous fat, or fat that lays directly under the skin. 

Dr Decotiis added: ‘It looks like she lost a lot of weight. Maybe even too much weight.’

Ariana Grande, channeling Audrey Hepburn in vintage Givenchy, has also been speculated to have reached for the injectable slimming drugs.

Ariana Grande, channeling Audrey Hepburn in vintage Givenchy, has also been speculated to have reached for the injectable slimming drugs

Dr Decotiis said: ‘It looks like she lost too much weight too. 

‘It also looks like her eyes are bulging out of their sockets a bit – which is a sign of a lot of weight loss and could actually be a thyroid disease too.’ 

The singer’s shoulder blades were prominent in her Audrey Hepburn-inspired look, which Dr Schimpf said was a sign of subcutaneous fat loss. 

He said: ‘The subcutaneous fat that’s under the skin that usually blends the bone in is kind of lost, so it collapses.’  

These are far from the only A-list stars rumored to have taken Ozempic.

Ozempic and Wegovy, two medications with the same active ingredient, semaglutide, have taken the entertainment industry by storm.

Ozempic, approved for diabetes management, has been prescribed off-label for weight loss since its debut in 2021. 

It has earned A-list fans who snapped up the weekly shots to slim down for a big role or red carpet appearance.

Kylie Jenner is also no stranger to Ozempic speculation, which heightens when the reality star publicly appears in an ensemble that accentuates her tiny waist

Rumors that writer and actor Mindy Kaling uses one of the slimming medications have persisted since late 2022, but the mother of three has shared that she enjoys outdoor exercise and continues to ‘eat what I like’—just ‘less of it’

Those rumors have dogged writer and actor Mindy Kaling since late 2022, but the mother of three has said she enjoys exercising outdoors and continues to ‘eat what I like to eat’ – but ‘less of it.’

Kylie Jenner is also no stranger to Ozempic speculation, which heightens when the reality star publicly appears in an ensemble that accentuates her tiny waist.

But she, like Ms Kaling, has tried to squash those rumors, telling British Vogue: ‘I’m back at my weight I was before I had my daughter and son, and people are putting side-by-sides of me three months postpartum. I’m like: “Does everyone forget that I had two children, and I gained 60 pounds both pregnancies?”’

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